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1. Parametric, Optimization-Based Study on the Feasibility of a Multisegment Antisolvent Crystallizer for in Situ Fines Removal and Matching of Target Size Distribution

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   Contributor(s):: Ridder, Bradley J., Majumder, Aniruddha, Nagy, Zoltan K.

   We have computationally investigated the use of the multisegment, multiaddition, plug-flow crystallizer (MSMA-PFC) for use in producing pharmaceutical crystals. A population balance framework was used to model the crystallization process. The dissolution of crystals can be modeled when solubility...

2. Optimization in seeded cooling crystallization: A parameter estimation and dynamic optimization study

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   Contributor(s):: Nowee, S. Mostafa, Abbas, Ali, Romagnoli, Jose A.

   In this solution crystallization study, a population balance model that predicts the crystal size distribution (CSD) is used for targeting, by optimization, the product mean size and the coefficient of variation of the final CSD. The model is robust over a wide range of conditions and predicts...

3. Continuous Pharmaceutical Crystallization from Solution

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   Contributor(s):: Price, CJ

   Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing