Effect of force feeder on tablet strength during compression
Contributor(s):: Narang, Ajit S., Rao, Venkatramana M., Guo, Hang, Lu, Jian, Desai, Divyakant S.
Mechanical strength of tablets is an important quality attribute, which depends on both formulation and process. In this study, the effect of process variables during compression on tablet tensile strength and tabletability (the ratio of tensile strength to compression pressure) was investigated...
Development and Optimization of a Wet Granulation Process at Elevated Temperature for a Poorly Compactible Drug Using Twin Screw Extruder for Continuous Manufacturing
Contributor(s):: Meena, Anuprabha K, Desai, Divyakant, Serajuddin,, Abu T. M.
The objective of this study was to enhance tabletability of a poorly compactible drug, acetaminophen, by wet granulation using twin screw extruder at high temperature. It was desired that there would be minimum amounts of excipients used and the granules obtained after extrusion would be dry and...