Discovery and mechanistic study of a photocatalytic indoline dehydrogenation for the synthesis of elbasvir
Contributor(s):: Susanne, Flavien, Martin, Benjamin, Aubry, Michel, Sedelmeier, Joerg, Lima, Fabio, Sevinc, Serbuelent, Piccioni, Lorenzo, Haber, Julien, Schenkel, Berthold, Venturoni, Francesco
Elbasvir is a potent NS5A antagonist for the treatment of chronic hepatitis C. A seemingly trivial indoline oxidation en route to the target compound was complicated by epimerization of a stereogenic hemiaminal center under most standard oxidation conditions. To address this issue, a novel...