Enhancing the Poor Flow and Tableting Problems of High Drug-Loading Formulation of Canagliflozin Using Continuous Green Granulation Process and Design-of-Experiment Approach
Contributor(s):: Almutairy, Bjad K., Khafagy, El-Sayed, Alalaiwe, Ahmed, Aldawsari, Mohammed F., Alshahrani, Saad M., Alsulays, Bader B., Alshetaili, Abdullah S., Alshehri, Sultan M, Fayed, Mohamed H.
Maximization of drug-loading can significantly reduce the size of dosage form and consequently decrease the cost of manufacture. In this Research Article, two challenges were addressed: poor flow and tableting problems of high-drug loading (>70%) formulation of canagliflozin (CNG), by adopting...