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Tags: high loading

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  1. Process optimization for continuous extrusion wet granulation

    Contributor(s):: Tan, L, Carella, AJ, Ren, YK, Lo, JB

    Three granulating binders in high drug-load acetaminophen blends were evaluated using high shear granulation and extrusion granulation. A polymethacrylate binder enhanced tablet tensile strength with rapid disintegration in simulated gastric fluid, whereas polyvinylpyrrolidone and hydroxypropyl...