Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production - A critical review
Contributor(s):: Kumar, Ashish, Gernaey, Krist V., De Beer, Thomas, Nopens, Ingmar
The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-wise process, is now also transformed into a series of continuous operations. Some operations such as tabletting and milling are already performed in continuous mode, while the adaptation towards a complete...
Converting a batch based high -shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets
Contributor(s):: Taipale-Kovalainen, Krista, Ketolainen, Jarkko, Korhonen, Ossi, Ervasti, Tuomas
When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies which can be adopted. Theoretically, the most straightforward way would be to proceed with the corresponding processing principles, for...