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Tags: Hot melt extrusion /Twin screw extrusion /Ibuprofen / Nicotinamide

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  1. Monitoring ibuprofen–nicotinamide cocrystal formation during solvent free continuous cocrystallization (SFCC) using near infrared spectroscopy as a PAT tool

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    09 Jun 2023 | Contributor(s):: Kelly, A.L., Gough, T., Dhumal, R.S., Halsey, S.A., Paradkar, A.

    The purpose of this work was to explore NIR spectroscopy as a PAT tool to monitor the formation of ibuprofen and nicotinamide cocrystals during extrusion based solvent free continuous cocrystallization (SFCC). Drug and co-former were gravimetrically fed into a heated co-rotating twin screw...