Resources (1-2 of 2)

1. Liquid API feeding in pharmaceutical HME: Novel options in solid dosage manufacturing

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   Peer-reviewed journal | 18 Jan 2024 | Contributor(s):: Simone Eder, Aygün Doğan, Johannes Khinast, Stephan Sacher, Martin Spoerk, Lisa Kuchler

   Hot melt extrusion (HME) is a common unit operation. It is broadly applicable in the pharmaceutical industry and can be implemented in a continuous manufacturing line. However, the conventional way of active pharmaceutical ingredient (API) feeding with a pre-blend consisting of a powdered API...

2. Application of FT-NIR Analysis for In-line and Real-Time Monitoring of Pharmaceutical Hot Melt Extrusion: a Technical Note

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Vo, Anh Q., He, Herman, Zhang, Jiaxiang, Martin, Scott, Chen, Rui, Repka, Michael A.

   Continuous manufacturing, a gaining interest paradigm in the pharmaceutical industry, requires in-process monitoring of critical process parameters to ensure product consistency. This study demonstrated the application of Fourier transform near-infrared (FT-NIR) spectroscopy in conjunction with...