Integrated multi-step continuous flow synthesis of daclatasvir without intermediate purification and solvent exchange
24 Apr 2024 | Contributor(s):: Rana, Abhilash, Mahajan, Bhushan, Ghosh, Subhash, Srihari, Pabbaraja, Singh, Ajay K.
The rapid transmission of viral diseases can cause massive economic damage and loss of life. The manufacture of most anti-viral drugs is normally carried out using batch synthesis which typically requires long production times (3–15 days) and significant manpower and infrastructure. The...
Multi-step Flow Synthesis of the Anthelmintic Drug Praziquantel
24 Apr 2024 | Contributor(s):: Phull, Manjinder Singh, Bohara, Chander Singh, Gundla, Rambabu, Mainkar, Prathama S., Jadav, Surender Singh
Praziquantel (PZQ; Brand name: Biltricide) is categorized as an anthelminthic drug, and it is used for the treatment of Schistosomiasis and other parasitic infections. The World Health Organization (WHO) has classified it as one of the essential and emergency medicines needed across the globe....