Scalable and Sustainable Synthesis of Calcium Dobesilate via Integrated Five-Step Continuous-Flow Chemistry
Contributor(s):: Liu, Minjie, Wan, Li, Gao, Liang, Cheng, Dang, Jiang, Meifen, Chen, Fen-Er
Calcium dobesilate is a widely prescribed veno-tonic drug in over 60 countries for treating chronic venous disease, diabetic retinopathy, and hemorrhoidal attack symptoms. Although two batchwise manufacturing routes to this treatment have been developed, the drawbacks, such as poor...