Granulation of increasingly hydrophobic formulations using a twin screw granulator
Contributor(s):: Yu, Shen, Reynolds, Gavin K., Huang, Zhenyu, de Matas, Marcel, Salman, Agba D.
The application of twin screw granulation in the pharmaceutical industry has generated increasing interest due to its suitability for continuous processing. However, an understanding of the impact of formulation properties such as hydrophobicity on intermediate and finished product quality has...
Examining drug hydrophobicity in continuous wet granulation within a twin screw extruder
Contributor(s):: Li, H., Thompson, M. R., O'Donnell, K. P.
The influence of active pharmaceutical ingredient (API) hydrophobicity on continuous wet granulation was studied in twin screw granulation utilizing foamed binder delivery. The APIs examined were caffeine, acetaminophen, ibuprofen and griseofulvin and the drug load was maintained constant at 15...