Influence of filler selection on twin screw foam granulation
Contributor(s):: Rocca, K. E., Weatherley, S., Sheskey, P. J., Thompson, M. R.
The influence of filler selection in wet granulation was studied for the novel case where the binder is delivered as an unstable, semi-rigid aqueous foam to an extrusion process. The work primarily examined the impact of differing concentrations of microcrystalline cellulose (Avicel PH (R) 101)...
Characterization of a novel hydroxypropyl methylcellulose (HPMC) direct compression grade excipient for pharmaceutical tablets
Contributor(s):: Allenspach, Carl, Timmins, Peter, Sharif, Shasad, Minko, Tamara
Controlled release tablets are important dosage forms enabling a slower release of the drug and better pharmacokinetics for some drugs and hydrophilic matrix tablets utilizing hydroxypropyl methylcellulose (HPMC) are one of the most common types. One of the main challenges with using HPMC is its...