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1. Transfer from High-Shear Batch to Continuous Twin Screw Wet Granulation: A Case Study in Understanding the Relationship Between Process Parameters and Product Quality Attributes

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   09 Jun 2023 | Contributor(s):: Beer, Paul, Wilson, David, Huang, Zhenyu, De Matas, Marcel

   A twin screw to high-shear batch granulation technology switch was evaluated for a pharmaceutical development project. Differences in granule (particle size distribution and porosity) and tablet (dissolution) quality attributes were analysed for both continuous and batch technologies. Liquid to...

2. The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

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   09 Jun 2023 | Contributor(s):: Nguyen, TTH, Khan, ABruce, LM, Forbes, C, O'Leary, RL, Price, CJ

   Sono-crystallisation has been used to enhance crystalline product quality particularly in terms of purity, particle size and size distribution. In this work, the effect of impurities and ultrasound on crystallisation processes (nucleation temperature, yield) and crystal properties (crystal size...

3. Optimization of a semi-batch tablet coating process for a continuous manufacturing line by design of experiments

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   09 Jun 2023 | Contributor(s):: Barimani, Shirin, Šibanc, Rok, Kleinebudde, Peter