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The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities
09 Jun 2023 | Contributor(s):: Nguyen, TTH, Khan, ABruce, LM, Forbes, C, O'Leary, RL, Price, CJ
Sono-crystallisation has been used to enhance crystalline product quality particularly in terms of purity, particle size and size distribution. In this work, the effect of impurities and ultrasound on crystallisation processes (nucleation temperature, yield) and crystal properties (crystal size...
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Optimal Dynamic Continuous Manufacturing of Pharmaceuticals with Recycle
09 Jun 2023 | Contributor(s):: Patrascu, Michael, Barton, Paul I.
Continuous manufacturing of pharmaceuticals is challenged by short campaigns due to the low volume of some products. This calls for optimization of the entire dynamic campaign to achieve the highest overall yields and productivity and to minimize waste. In this paper, we investigate how recycles...
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Crystallization of Cyclosporine in a Multistage Continuous MSMPR Crystallizer
09 Jun 2023 | Contributor(s):: Alvarez, Alejandro J., Singh, Aniruddh, Myerson, Allan S.
Crystallization processes can be batch or continuous. Potential advantages such as operating at steady state, small equipment size (relative to batch), and ability to recycle are encouraging the pharmaceutical industry to investigate continuous processes. In this work, a continuous cooling...
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Continuous Crystallization of Aliskiren Hemifumarate
09 Jun 2023 | Contributor(s):: Quon, JL, Zhang, HAlvarez, A, Evans, J, Myerson, AS, Trout, BL
Active ingredients in most pharmaceutical products are complex organic molecules that require crystallization as a purification and isolation step that results in a pure product at a high process yield. Knowledge of the operating conditions required to obtain crystals with the desired crystal...
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Complexation-Assisted Continuous Crystallization of Isomeric Systems with Nanofiltration Recycle
09 Jun 2023 | Contributor(s):: Vartak, S, Myerson, AS
In API-impurity systems consisting of structural isomers, the impurity has a strong affinity to incorporate into the host crystal owing to their identical molecular weight and similar structure. Conventional successive recrystallization turns out to be an unattractive purification strategy in...