Resources (1-3 of 3)

1. Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process

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   Contributor(s):: Van Bockstal, Pieter-Jan, Mortier, Severine Therese F. C., De Meyer, Laurens, Corver, Jos, Vervaet, Chris, Nopens, Ingmar, De Beer, Thomas

   Conventional pharmaceutical fieeze-drying is an inefficient and expensive batch-wise process, associated with several disadvantages leading to an uncontrolled end product variability. The proposed continuous alternative, based on spinning the vials during freezing and on optimal energy supply...

2. Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying

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   Contributor(s):: De Meyer, Laurens, Lammens, Joris, Vanbillemont, Brecht, Van Bockstal, Pieter Jan, Corver, Jos, Vervaet, Chris, Friess, Wolfgang, De Beer, Thomas

   The applicability of DCCs in a continuous freeze-drying concept based on spin freezing and infrared heating was evaluated. Maximum applicable filling volume was evaluated. Secondly the mechanistic model for the determination of the optimal dynamic infrared heater temperature during primary drying...

3. Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation

   out of 5 stars 

   Contributor(s):: Van Bockstal, Pieter-Jan, Corver, Jos, Mortier, Severine Therese F. C., De Meyer, Laurens, Nopens, Ingmar, Gernaey, Krist V., De Beer, Thomas

   The continuous freeze-drying concept based on spinning the vials during freezing and on non-contact energy transfer via infrared (IR) radiation during drying, improves process efficiency and product quality (uniformity) compared to conventional batch freeze-drying. Automated control of this...