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1. Inline UV/Vis spectroscopy as PAT tool for hot-melt extrusion

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   09 Jun 2023 | Contributor(s):: Wesholowski, Jens, Prill, Sebastian, Berghaus, Andreas, Thommes, Markus

   Hot-melt extrusion on co-rotating twin screw extruders is a focused technology for the production of pharmaceuticals in the context of Quality by Design. Since it is a continuous process, the potential for minimizing product quality fluctuation is enhanced. A typical application of hot-melt...

2. Development of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation

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   09 Jun 2023 | Contributor(s):: Harting Julia, Kleinebudde, Peter

   Raman spectroscopy was evaluated as a process analytical technology (PAT) tool for continuous API quantification during twin-screw wet granulation. Therefore, a Raman probe was implemented in front of the granulator barrel. This setup enabled the collection of Raman spectra upon a constant...