Near Infrared Method Development for a Continuous Manufacturing Blending Process
09 Jun 2023 | Contributor(s):: Colon, Yleana, Florian, Miguel, Acevedo, David, Mendez, Rafael, Romañach, Rodolfo
Purpose This study describes the validation of a near infrared spectroscopic method for monitoring a continuous manufacturing system. The achievement of this goal requires determining the near infrared (NIR) method’s accuracy, precision, obtaining an estimate of the sample volume analyzed, and...
In-Line Quantification of Drug and Excipients in Cohesive Powder Blends by near Infrared Spectroscopy
09 Jun 2023 | Contributor(s):: Liew, C. V., Karande, A. D., Heng, P. W. S
This work was aimed at investigating the utility of near infrared (NIR) spectroscopy for simultaneous in-line quantification of drug and excipients in cohesive powder blends in a bin blender. A model formulation containing micronized chlorpheniramine maleate (μCPM), lactose, microcrystalline...