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1. Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876

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   24 Apr 2024 | Contributor(s):: Gao, Feng, Zhang, Guowei, Gu, Wenting, Zhang, Zhenfeng, Liu, Zhiqing, Zhang, Wanbin, Li, Jing

   Previously, the first asymmetric synthesis of anti-tuberculosis agent TBAJ-876 had been successfully achieved using a synergistic Li/Li catalysis approach, yielding excellent results on a 5 g scale. However, scaling up the process presents significant challenges due to its poor repeatability and...

2. A Continuous Process for Manufacturing Apremilast. Part II: Process Characterization to Establish a Parametric Control Strategy

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   Peer-reviewed journal | 03 Apr 2024 | Contributor(s):: Griffin, Daniel J., Avci, Nadide Hazal, Sarkar, Nandini, Fostinis, James D., Klitzing, Nicholas, Murray, James I., Wimalasinghe, Rasangi, Spada, Simone, Zeng, Alicia, Beaver, Matthew G., Hsieh, Hsiao-Wu

   This is Part II of a series on the development and characterization of an integrated continuous manufacturing (CM) process developed for the penultimate step in the synthesis of the drug substance Apremilast (Otezla). Part I gives the development history and highlights the achieved process...

3. Separation and Purification in the Continuous Synthesis of Fine Chemicals and Pharmaceuticals

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: O'Mahony, M, Ferguson, SStelzer, T, Myerson, A

   The use to both chemists and chemical engineers working in flow synthesis, this chapter provides a summary of separation and purification operations that can be applied to flow synthesis reaction streams. Both single and biphasic separations for the liquid phase are detailed. Separation and...

4. Dynamic flowsheet model development and digital design of continuous pharmaceutical manufacturing with dissolution modeling of the final product

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   Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Nagy, Brigitta, Szilágyi, Botond Domokos, András Vészi, Blanka, Tacsi, Kornélia, Rapi, Zsolt, Pataki, Hajnalka, Marosi, György, Nagy, Zoltán K., Nagy, Zsombor Kristóf

   The integration of continuous unit operations imposes a challenge on the pharmaceutical companies aspiring to achieve plant-wide continuous manufacturing due to the additional complexity of the dynamic interactions, process control and quality assurance. To overcome this challenge, flowsheet...