All Categories (1-2 of 2)

1. End-to-end continuous manufacturing of conventional compressed tablets: From flow synthesis to tableting through integrated crystallization and filtration

   out of 5 stars 

   Contributor(s):: Domokos, A, Nagy, BGyurkes, M, Farkas, A, Tacsi, K, Pataki, H, Liu, YC, Balogh, A, Firth, P, Szilagyi, B, Marosi, G, Nagy, ZK

   An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level for the first time. The output reaction mixture of the flow synthesis of acetylsalicylic acid was crystallized continuously in a...

2. Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line: Rapid and deep process understanding

   out of 5 stars 

   Contributor(s):: Domokos, András, Pusztai, Éva, Madarász, Lajos, Nagy, Brigitta, Gyürkés, Martin, Farkas, Attila (24372641300), Fülöp, Gergő, Casian, Tibor, Szilágyi, Botond., Nagy, Zsombor Kristóf

   Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw wet granulation, vibrational fluid-bed drying and...