Continuous Flow Chemistry of Metal Mediated Carboxylation and α-Arylation Reactions
Contributor(s):: Venkatraman, Sripathy, Tweedie, Scott, McLaws, Mark, Lathbury, David
Utility of continuous flow chemistry in a carboxylation reaction and palladium-mediated α-arylation reaction is described. A two-step carboxylation reaction of an aryl group involving an anion formation, followed by quench with gaseous carbon dioxide was developed on small scale using HDPE tubes...