A Concise Flow Synthesis of Efavirenz
10 May 2024 | Contributor(s):: Correia, Camille A., Gilmore, Kerry, McQuade, D. Tyler, Seeberger, Peter H.
Efavirenz is an essential medicine for the treatment of HIV, which is still inaccessible to millions of people worldwide. A novel, semi-continuous process provides rac-Efavirenz with an overall yield of 45 %. This streamlined proof-of-principle synthesis relies on the efficient copper-catalyzed...