Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity
Contributor(s):: Shahid, M, Sanxaridou, GOttoboni, S, Lue, L, Price, C
Washing is a key step in pharmaceutical isolation to remove the unwanted crystallization solvent (mother liquor) from the active pharmaceutical ingredient (API) filter cake. This study looks at strategies for optimal wash solvent selection, which minimizes the dissolution of API product crystals...
Developing a Batch Isolation Procedure and Running It in an Automated Semicontinuous Unit: AWL CFD25 Case Study
Contributor(s):: Ottoboni, S, Shahid, MSteven, C, Coleman, S, Meehan, E, Barton, A, Firth, P, Sutherland, R, Price, CJ
A key challenge during the transition from laboratory/small batch to continuous manufacturing is the development of a process strategy that can easily be adopted for a larger batch/continuous process. Industrial practice is to develop the isolation strategy for a new drug/process in batch using...