Quantitative Solution Measurement for the Selection of Complexing Agents to Enable Purification by Impurity Complexation
Contributor(s):: Weber, CC, Wood, GPFKunov-Kruse, AJ, Nmagu, DE, Trout, BL, Myerson, AS
The removal of carboxylic acid impurities from amide targets has been accomplished through crystallization featuring a complexing agent in solution. The interaction between the complexing agents and impurities was examined using isothermal titration calorimetry and the free energy of association...