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1. Population Balance Model Development Verification and Validation of Cooling Crystallization of Carbamazepine

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   09 Jun 2023 | Contributor(s):: Liu, Yiqing C., Acevedo, David Yang, Xiaochuan Naimi, Sean, Wu, Wei-Lee, Pavurala, Naresh, Nagy, Zoltan K., O'Connor, Thomas F.

   Using process modeling to understand process dynamics and potentially explore the design space of a crystallization process is difficult because of its complex nature with many factors at play, such as initial concentration, supersaturation, seeding strategy, and flow pattern. In this work, a...

2. Nucleation and Growth Kinetics for Combined Cooling and Antisolvent Crystallization in a Mixed-Suspension, Mixed-Product Removal System: Estimating Solvent Dependency

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   09 Jun 2023 | Contributor(s):: Schall, JM, Mandur, JSBraatz, RD, Myerson, AS

   Combined cooling and antisolvent crystallization is a critical unit operation in pharmaceutical manufacturing, especially for heat-sensitive or poorly soluble active pharmaceutical ingredients. The model-based design of these systems relies on the accuracy of the underlying growth and nucleation...

3. Multi-Impurity Adsorption Model for Modeling Crystal Purity and Shape Evolution during Crystallization Processes in Impure Media

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   09 Jun 2023 | Contributor(s):: Borsos, Akos, Majumder, Aniruddha, Nagy, Zoltan K.

   The impurity effect on the crystal properties, such as particle size and shape distribution, is significant, having significant impact on the downstream processes as well as on the product effectiveness. Currently very few studies exist that provide a quantitative model to describe crystal purity...