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Tags: Lanabecestat

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  1. Process Intensification and Integration Studies for the Generation of a Key Aminoimidazole Intermediate in the Synthesis of Lanabecestat

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    09 Jun 2023 | Contributor(s):: Znidar, D, Cantillo, DInglesby, P, Boyd, A, Kappe, CO

    An improved synthetic procedure for the multistep synthesis of aminoimidazole 6, a key intermediate in the preparation of lanabecestat (AZD3293/LY3314814), is described. Under intensified conditions (high temperature and elevated pressure), the overall processing time and required amounts of...