Implementing Feedback Granule Size Control in a Continuous DryGranulation Line Using Controlled Impeller Speed of the GranulationUnit, Compaction Force and Gap Width
Contributor(s):: Wilms, Annika, Teske, Andreas, Meier, Robin, Wiedey, Raphael, Kleinebudde, Peter
Purpose: In continuous manufacturing of pharmaceuticals, dry granulation is of interest because of its large throughput capacity and energy efficiency. In order to manufacture solid oral dosage forms continuously, valid control strategies for critical quality attributes should be established. To...