Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions
Contributor(s):: Jaman, Z, Sobreira, TJPMufti, A, Ferreira, CR, Cooks, RG, Thompson, DH
Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has been synthesized using continuous flow methodology. Desorption electrospray ionization mass spectrometry (DESI-MS) was used to quickly explore a large number of reaction conditions for one of the reaction...
Flow synthesis kinetics for lomustine, an anti-cancer active pharmaceutical ingredient
Contributor(s):: Diab, S, Raiyat, M, Gerogiorgis, DI
Continuous flow synthesis of active pharmaceutical ingredients (APIs) can offer access to process conditions that are otherwise hazardous when operated in batch mode, resulting in improved mixing and heat transfer, which enables higher yields and greater reaction selectivity. Reaction kinetic...