-
Loss-in-Weight Feeding Trials Case Study: Pharmaceutical Formulation
09 Jun 2023 | Contributor(s):: Engisch, WE, Muzzio, FJ
This article presents a case study of a continuous feeding strategy for five pharmaceutical components (active pharmaceutical ingredient (API), Prosolv HD90, crospovidone, magnesium stearate, and colloidal silicon dioxide), for the purpose of developing a direct compression continuous...
-
Identifying a Loss-in-Weight Feeder Design Space Based on Performance and Material Properties
09 Jun 2023 | Contributor(s):: Li, Tianyi, Scicolone, James V. Sanchez, Eric, Muzzio, Fernando J.
Powder properties, such as density and adhesion, can cause large variability in the flow rate of ingredients fed from feeders, which can propagate through the system. Knowing an ideal range of operation and correlating powder properties to process performance can result in faster optimization of...
-
Feedrate deviations caused by hopper refill of loss-in-weight feeders
09 Jun 2023 | Contributor(s):: William E. Engisch, Fernando J. Muzzio
Continuous powder processing requires accurate and consistent feed streams of the raw materials which makes loss-in-weight feeders invaluable. Periodic hopper refill of the feeders, which is needed for continuous operation, can lead to inconsistent and poor feeding performance. This paper...
-
Control of a system of loss-in-weight feeders for drug product continuous manufacturing
09 Jun 2023 | Contributor(s):: Hanson, Joshua
Loss-in-weight (LIW) feeders are used to dispense individual materials to the downstream unit operations in continuous drug product manufacturing processes. The purpose of this work was to identify potential material feeding failure modes and demonstrate how a ratio control loop can be used to...