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Development of a novel method for the continuous blending of carrier-based dry powders for inhalation using a co-rotating twin-screw extruder
Contributor(s):: Spahn, Jamie E., Hefnawy, Amr, Smyth, Hugh D. C., Zhang, Feng
Twin-screw extruders are useful in tuning certain product characteristics due to the ability to greatly modify screw profiles as well as operating parameters. However, their use has not yet been applied to dry powder inhalation. In this study the feasibility of using a twin-screw extruder to...
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Evaluation of the lubrication mechanism at various rotation speeds and granule filling levels in a container mixer using a thermal effusivity sensor
Contributor(s):: Uchiyama, Jumpei, Aoki, Shigeru
To Research Article the detailed mechanism of the lubrication process using the thermal effusivity sensor, the relationships of the lubrication progress with the pattern of powder flow, the rotation speed and the filling level were investigated. The thermal effusivity profile was studied as a...
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Effect of force feeder on tablet strength during compression
Contributor(s):: Narang, Ajit S., Rao, Venkatramana M., Guo, Hang, Lu, Jian, Desai, Divyakant S.
Mechanical strength of tablets is an important quality attribute, which depends on both formulation and process. In this study, the effect of process variables during compression on tablet tensile strength and tabletability (the ratio of tensile strength to compression pressure) was investigated...