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Tags: Mannitol

Resources (1-5 of 5)

  1. Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Contributor(s):: Vanhoorne, V., Almey, R., De Beer, T., Vervaet, C.

    In current study, it was investigated if the moisture-mediated polymorphic transition from δ- to β-mannitol during twin screw granulation (TSG) also took place in high drug loaded formulations and if the specific granule morphology associated with the polymorphic transition could enable tableting...

  2. Twin Screw Granulation: Effects of Properties of Primary Powders

    Contributor(s):: Lute, Sushma, V, Dhenge, Ranjit M., Salman, Agba D.

    Lactose and mannitol are some of the most commonly used powders in the pharmaceutical industry. The limited Research Article published so far highlights the effects of process and formulation parameters on the properties of the granules and the tablets produced using these two types of powders...

  3. Twin-screw granulation and high-shear granulation: The influence of mannitol grade on granule and tablet properties

    Contributor(s):: Megarry, Andrew, Taylor, Agnes, Gholami, Aida, Wikstrom, Hakan, Tajarobi, Pirjo

    Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice of input grade has been shown to impact granule properties....

  4. Faster to First-time-in-Human: Prediction of the liquid solid ratio for continuous wet granulation

    Contributor(s):: Junnila, A, Wikstrom, HMegarry, A, Gholami, A, Papathanasiou, F, Blomberg, A, Ketolainen, J, Tajarobi, P

    In early development, when active pharmaceutical ingredient (API) is in short supply, it would be beneficial to reduce the number of experiments by predicting a suitable L/S ratio before starting the product development. The aim of the study was to decrease development time and the amount of API...

  5. A quality by design approach to investigate the effect of mannitol and dicalcium phosphate qualities on roll compaction

    Contributor(s):: Souihi, Nabil, Dumarey, Melanie, Wikstrom, Hakan, Tajarobi, Pirjo, Fransson, Magnus, Svensson, Olof, Josefson, Mats, Trygg, Johan

    Roll compaction is a continuous process for solid dosage form manufacturing increasingly popular within pharmaceutical industry. Although roll compaction has become an established technique for dry granulation, the influence of material properties is still not fully understood. In this study, a...