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Prediction of tablet weight variability in continuous manufacturing
Contributor(s):: Razavi, Sonia M., Scicolone, James, Snee, Ronald D., Kumar, Ashish, Bertels, Johny, Cappuyns, Philippe, Van Assche, Ivo, Cuitino, Alberto M, Muzzio, Fernando
This paper provides a method for prediction of weight variability of tablets made in rotary tablet presses as a function of material attributes and processing parameters. The goal was to be able to predict whether or not a formulation is suitable for direct compaction continuous manufacturing...
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Mapping key process parameters to the performance of a continuous dry powder blender in a continuous direct compression system
Contributor(s):: Palmer, J, Reynolds, GK, Tahir, F, Yadav, IK, Meehan, E, Holman, J, Bajwa, G
This work aims to expand the typical raw material attributes that can successfully be processed on a continuous direct compression line with a particular focus on the continuous dry powder blender. Three grades of Acetaminophen were investigated as model active pharmaceutical ingredients and...
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Influence of material properties and equipment configuration on loss-in-weight feeder performance for drug product continuous manufacture
Contributor(s):: Yadav, IK, Holman, JMeehan, E, Tahir, F, Khoo, J, Taylor, J, Benedetti, A, Aderinto, O, Bajwa, G
A programme of work on continuous tablet manufacturing was completed as part of a UK based collaborative Research Article project (REMEDIES: RE-configuring MEDIcines End-to-end Supply) to evaluate the operating space of the continuous platform with respect to material properties. Loss-in-weight...