Pharmaceutical excipients properties and screw feeder performance in continuous processing lines: a Quality by Design (QbD) approach
Contributor(s):: Santos, Bianca, Carmo, Flavia, Schlindwein, Walkiria, Muirhead, Gordon, Rodrigues, Carlos, Cabral, Lucio, Westrup, Julian, Pitt, Kendal
Screw feeder performance is a critical aspect in continuous manufacturing processes. Pharmaceutical excipients, such as mannitol, microcrystalline cellulose, lactose monohydrate, and anhydrous dibasic calcium phosphate can present problems in ensuring a continuous stable feed rate due to their...