Peer-reviewed journal (1-3 of 3)

1. Using residence time distribution in pharmaceutical solid dose manufacturing–A critical review

   out of 5 stars 

   Contributor(s):: Bhalode, Pooja, Tian, Huayu Gupta, Shashwat Razavi, Sonia M Roman-Ospino, Andres Talebian, Shahrzad Singh, Ravendra Scicolone, James V Muzzio, Fernando J, Ierapetritou, Marianthi

   While continuous manufacturing (CM) of pharmaceutical solid-based drug products has been shown to be advantageous for improving the product quality and process efficiency in alignment with FDA’s support of the quality-by-design paradigm (Lee, 2015; Ierapetritou et al., 2016; Plumb, 2005; Schaber,...

2. Tracking raw material flow through a continuous direct compression line. Part II of II: Predicting dynamic changes in quality attributes of tablets due to disturbances in raw material properties using an independent residence time distribution model

   out of 5 stars 

   Contributor(s):: Peterwitz, M, Buchgeister, SMeier, R, Schembecker, G

   Continuous manufacturing of pharmaceuticals promises many advantages regarding economics and quality. However, tracing deviating material in such processes is much more challenging than in batch processes due to axial back-mixing. The literature has proven the traceability of disturbances in the...

3. Systematic framework for implementation of material traceability into continuous pharmaceutical tablet manufacturing process

   out of 5 stars 

   Contributor(s):: Billups, Matthew, Singh, Ravendra

   Purpose: With the applications of more advanced manufacturing technologies being applied to the pharmaceutical industry, continuous processes are at the forefront of innovation. One area that is highly desired to be systematically investigated is material traceability in continuous manufacturing...