Resources (1-3 of 3)

1. RTD-based material tracking in a fully-continuous dry granulation tableting line

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   Contributor(s):: Martinetz, M. C., Karttunen, A-P, Sacher, S., Wahl, P., Ketolainen, J., Khinast, J. G., Korhonen, O

   Continuous manufacturing (CM) offers quality and cost-effectiveness benefits over currently dominating batch processing. One challenge that needs to be addressed when implementing CM is traceability of materials through the process, which is needed for the batch/lot definition and control...

2. Material tracking in a continuous direct capsule-filling process via residence time distribution measurements

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   Contributor(s):: Kruisz, Julia, Rehrl, Jakob, Faulhammer, Eva, Witschnigg, Andreas, Khinast, Johannes G.

   Continuous production of pharmaceuticals requires traceability from the raw material to the final dosage form. With that regard, understanding the residence time distribution (RTD) of the whole process and its unit operations is crucial. This work describes a structured approach to characterizing...

3. Measurement of residence time distributions and material tracking on three continuous manufacturing lines

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   Contributor(s):: Karttunen, Anssi-Pekka, Hörmannb,Theresa, De Leersnyder, Fien, Ketolainen, Jarkko, De Beer, Thomas, Hsiao, Wen-Kai, Korhonen, Ossi

   Over the recent decade, benefits of continuous manufacturing (CM) of pharmaceutical products have been acknowledged widely. In contrast to batch processes, the product is not physically separated into batches in CM, which creates a few challenges. Product release is done for batches that should...