Model identification and control of solution crystallization processes: a review
09 Jun 2023 | Contributor(s):: Rawlings, James B., Miller, Stephen M., Witkowski, Walter R.
The modeling of crystal quality (size, shape, and purity) is discussed. Numerical methods for the model solution are reviewed including collocation and Galerkin's method on finite elements. Measurement technologies for on-line crystal size distribution are presented. The difficulties with laser...
Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production - A critical review
09 Jun 2023 | Contributor(s):: Kumar, Ashish, Gernaey, Krist V., De Beer, Thomas, Nopens, Ingmar
The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-wise process, is now also transformed into a series of continuous operations. Some operations such as tabletting and milling are already performed in continuous mode, while the adaptation towards a complete...