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Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)
09 Jun 2023 | Contributor(s):: Tan, D, Loots, L, Friscic, T
This overview highlights the emergent area of mechanochemical reactions for making active pharmaceutical ingredients (APIs), and covers the latest advances in the recently established area of mechanochemical screening and synthesis of pharmaceutical solid forms, specifically polymorphs,...
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Mechanochemistry Can Reduce Life Cycle Environmental Impacts of Manufacturing Active Pharmaceutical Ingredients
09 Jun 2023 | Contributor(s):: Galant, O, Cerfeda, GMcCalmont, AS, James, SL, Porcheddu, A, Delogu, F, Crawford, DE, Colacino, E, Spatari, S
The scale-up of mechanochemical methods could play a transformative role in making manufacturing processes in the pharmaceutical industry greener by eliminating solvent use and recovery. Combined with energy-efficient continuous processing that consolidates reaction steps, mechanochemistry's...
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Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch to the Large-Scale Extrusion Processing
09 Jun 2023 | Contributor(s):: Stolar, T, Lukin, STireli, M, Sovic, I, Karadeniz, B, Kerekovic, I, Matijasic, G, Gretic, M, Katancic, Z, Dejanovic, I, di, Michiel, M, Halasz, I, Uzarevic, K
We demonstrate a controllable mechanochemical synthesis of cocrystal polymorphs of ascorbic acid (vitamin C) and nicotinamide (vitamin B3) on different scales and without using bulk solvents. Next to the previously described polymorph of the 1:1 cocrystal, which is one of the first cocrystals...
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Continuous, one-step synthesis of pharmaceutical cocrystals via hot melt extrusion from neat to matrix-assisted processing - State of the art
09 Jun 2023 | Contributor(s):: Gajda, Maciej, Nartowski, Karol P., Pluta, Janusz, Karolewicz, Bożena
Use of hot melt extrusion (HME) as continuous manufacturing process in the cocrystal synthesis is of increasing interest from both industrial and academic perspective and it is seen as a newly developing branch of mechanochemistry with possible broad application in single step synthesis and...
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Assessing the Greenness of Mechanochemical Processes with the DOZN 2.0 Tool br
09 Jun 2023 | Contributor(s):: Sharma, P, Vetter, CPonnusamy, E, Colacino, E
As the demand increases for more sustainable chemical production,mechanochemical processes have been proposed as greener alternatives to traditional manufacturing methods. To support the transition to mechanochemical processes,quantitative assessment methods must be developed to measure and...