Resources (1-2 of 2)

1. Solid-liquid axial dispersion performance of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions using a non-invasive dual backlit imaging technique

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   09 Jun 2023 | Contributor(s):: Onyemelukwe, II, Nagy, ZK, Rielly, CD

   A dual backlit imaging technique has been developed for liquid and solid phase residence time distribution (RTD) measurements in a mesoscale (millilitre) continuous oscillatory flow crystalliser with smooth periodic constrictions (herein known as the SPC mesoscale crystalliser). The pixel-based...

2. Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride

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   09 Jun 2023 | Contributor(s):: Gerardy, R, Winter, MVizza, A, Monbaliu, JCM

   The batch-to-flow translation of inter-and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both inter-and intramolecular strategies imply the telescoping of multiple processing steps and the...