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Particle Shape Manipulation and Optimization in Cooling Crystallization Involving Multiple Crystal Morphological Forms
09 Jun 2023 | Contributor(s):: Wang, Xue, Ma, CY, Wan, Jian
A population balance model for predicting the dynamic evolution of crystal shape distribution is further developed to simulate crystallization processes in which multiple crystal morphological forms co-exist and transitions between them can take place. The new model is applied to derive the...
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Control of Drug-Excipient Particle Attributes with Droplet Microfluidic-based Extractive Solidification Enables Improved Powder Rheology
09 Jun 2023 | Contributor(s):: Ng, DZL, Nelson, AZWard, G, Lai, D, Doyle, PS, Khan, SA
Purpose Industrial implementation of continuous oral solid dosage form manufacturing has been impeded by the poor powder flow properties of many active pharmaceutical ingredients(APIs). Microfluidic droplet-based particle synthesis is an emerging particle engineering technique that enables the...
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Continuous manufacture of polymeric cellular dosage forms
09 Jun 2023 | Contributor(s):: Blaesi, Aron H, Saka, Nannaji
The most prevalent pharmaceutical dosage forms at present are granular solids in the form of oral tablets and capsules. While effective in releasing drug rapidly upon contact with gastrointestinal fluid, their manufacture, which relies on particulate processing, is fraught with difficulties...
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Advanced methodologies for cocrystal synthesis
09 Jun 2023 | Contributor(s):: Douroumis, D, Ross, SA, Nokhodchi, A
Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties...