Real-time process monitoring in a semi-continuous fluid-bed dryer - microwave resonance technology versus near-infrared spectroscopy
09 Jun 2023 | Contributor(s):: Peters, Johanna, Teske, Andreas, Taute, Wolfgang, Döscher, Claas, Höft, Michael, Knöchel, Reinhard, Breitkreutz, Jörg
The trend towards continuous manufacturing in the pharmaceutical industry is associated with an increasing demand for advanced control strategies. It is a mandatory requirement to obtain reliable real-time information on critical quality attributes (CQA) during every process step as the decision...
In-line monitoring of granule moisture in fluidized-bed dryers using microwave resonance technology
09 Jun 2023 | Contributor(s):: Buschmueller, Caroline, Wiedey, Wolfgang, Doescher, Claas, Dressler, Jochen, Breitkreutz, Joerg
This is the first report on in-line moisture measurement of pharmaceutical products by microwave resonance technology. In order to meet the FDA's PAT approach, a microwave resonance sensor appropriate for pharmaceutical use was developed and implemented into two different fluidized-bed dryers....