Resources (1-3 of 3)

1. From form to function: Crystallization of active pharmaceutical ingredients

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   09 Jun 2023 | Contributor(s):: Variankaval, Narayan, Cote, Aaron S., Doherty, Michael F.

   In this perspective, we describe the state-of-the-art in API crystal product and process design, highlight barriers that currently prevent the production of better, cheaper crystalline products, and give our best estimate of where the field is going and should go during the next decade.

2. Experimental determination of residence time distribution in continuous dry granulation

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   09 Jun 2023 | Contributor(s):: Mangal, Haress, Kleinebudde, Peter

   With increasing importance of continuous manufacturing, the interest in integrating dry granulation into a continuous manufacturing line is growing. Residence time distribution measurements are of importance as they provide information about duration of materials within the process. These data...

3. Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line: Rapid and deep process understanding

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   09 Jun 2023 | Contributor(s):: Domokos, András, Pusztai, Éva, Madarász, Lajos, Nagy, Brigitta, Gyürkés, Martin, Farkas, Attila (24372641300), Fülöp, Gergő, Casian, Tibor, Szilágyi, Botond., Nagy, Zsombor Kristóf

   Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw wet granulation, vibrational fluid-bed drying and...