-
System-wide hybrid MPC–PID control of a continuous pharmaceutical tablet manufacturing process via direct compaction
09 Jun 2023 | Contributor(s):: Singh, Ravendra, Ierapetritou, Marianthi, Ramachandran, Rohit
The next generation of QbD based pharmaceutical products will be manufactured through continuous processing. This will allow the integration of online/inline monitoring tools, coupled with an efficient advanced model-based feedback control systems, to achieve precise control of process variables,...
-
Perspectives on the flexibility analysis for continuous pharmaceutical manufacturing processes
09 Jun 2023 | Contributor(s):: Yang, WH, Qian, WXYuan, ZH, Chen, BZ
Pharmaceutical continuous manufacturing, especially under the context of COVID-19 pandemic, is regarded as an emerging technology that can guarantee the adequate quality assurance and mitigate process risk while guaranteeing the desirable economic performance. Flexibility analysis is one approach...
-
Multi-dimensional population balance modeling and experimental validation of continuous powder mixing processes
09 Jun 2023 | Contributor(s):: Sen, Maitraye, Singh, Ravendra Vanarase, Aditya John, Joyce, Ramachandran, Rohit
It has been recognized that the application of quality by design (QbD) to continuous processing in the pharmaceutical industry leads to better process control, improved product quality and mitigates scale-up issues (Schaber et al., 2011), whereby a component of QbD involves the development...
-
Mechanistic modeling for systematic design and analysis of PAT systems
09 Jun 2023 | Contributor(s):: Singh, Ravendra, Samad, Noor Asma Fazli Abdul Gernaey, Krist V Woodley, John M, Gani, Rafiqul
Not available
-
Mathematical development and comparison of a hybrid PBM-DEM description of a continuous powder mixing process
09 Jun 2023 | Contributor(s):: Sen, Maitraye, Dubey, Atul Singh, Ravendra, Ramachandran, Rohit
This paper describes the development of a multidimensional population balance model (PBM) which can account for the dynamics of a continuous powder mixing/blending process. The PBM can incorporate the important design and process conditions and determine their effects on the various critical...
-
An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction
09 Jun 2023 | Contributor(s):: R Singh, M Ierapetritou, R Ramachandran
A novel manufacturing strategy based on continuous processing integrated with online monitoring tools coupled with efficient automatic feedback control system is highly desired for efficient Quality by Design (QbD) based manufacturing ofthe next generation of pharmaceutical products with optimal...