Magazine (1-3 of 3)

1. Model-predictive design, control and optimization of pharmaceutical process

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   09 Jun 2023 | Contributor(s):: Muzzio, F, Singh, R Chaudhury, A Rogers, A Ramachandran, R, Ierapetritou, M

   Applying model-predictive methods and a continuous process-control framework to a continuous tablet-manufacturing process. Currently, there is a high level of interest in the pharmaceutical industry in continuous-manufacturing strategies, integrated with online-monitoring tools, that are...

2. Flowsheet Models Modernize Pharmaceutical Manufacturing Design and Risk Assessment

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   09 Jun 2023 | Contributor(s):: Muzzio, Fernando, Singh, M Sebastian Escotet-Espinoza Ravendra, Lee Sau, Thomas O’Connor Marianthi, Ierapetritou, Lee Sharmista Chatterjee Rohit Ramachandran, Sen, Maitraye

   The pharmaceutical industry has recognized the value of implementing a systematic approach to drug product development where quality is built into the product and process. The FDA initiative on quality by design (QbD) promotes the design of the product and manufacturing process using principles...

3. Designing a novel continuous manufacturing plant with superior monitoring and control

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   09 Jun 2023 | Contributor(s):: Singh, Ravendra, Zhang, Jun Ierapetritou, Marianthi, Ramachandran, Rohit

   There is a growing interest in manufacturing the pharmaceutical product continuously . Along with other advantages , it provides an appropriate platform to implement suitable monitoring and control architecture, to improve the product quality and minimise product rejection and operating expenses....