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Tags: Monte Carlo simulation

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  1. Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data

    09 Jun 2023 | Contributor(s):: Liu, Huolong, Galbraith, S. C., Ricart, Brendon, Stanton, Courtney, Smith-Goettler, Brandye, Verdi, Luke, O'Connor, Thomas, Lee, Sau, Yoon, Seongkyu

    In this study, the influence of key process variables (screw speed, throughput and liquid to solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using a central composite face-centered (CCF) experimental design method. Regression models were developed to predict...

  2. Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation

    09 Jun 2023 | Contributor(s):: Van Bockstal, Pieter-Jan, Corver, Jos, Mortier, Severine Therese F. C., De Meyer, Laurens, Nopens, Ingmar, Gernaey, Krist V., De Beer, Thomas

    The continuous freeze-drying concept based on spinning the vials during freezing and on non-contact energy transfer via infrared (IR) radiation during drying, improves process efficiency and product quality (uniformity) compared to conventional batch freeze-drying. Automated control of this...