Modelling protein crystallisation using morphological population balance models
Contributor(s):: Liu, Jing J., Ma, Cai Y. Hu, Yang D., Wang, Xue Z.
Protein crystallisation is known to be affected by many factors and inherently difficult to control. Being able to model the crystal growth behaviour, especially at process scale for the population of particles in a crystalliser will no doubt greatly help the formulation and controlled...
Monitoring and digital design of the cooling crystallization of a high-aspect ratio anticancer drug using a two-dimensional population balance model
Contributor(s):: Szilágyi, Botond, Eren, Ayşe Quon, Justin L. Papageorgiou, Charles D., Nagy, Zoltán K.
The development of a process model for the batch cooling crystallization of an anticancer drug from Takeda Pharmaceuticals is presented. The compound forms needle-like crystals that exhibit significant variation in shape (aspect ratio) during the crystallization. The parameters of a...