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1. Population balance model-based multiobjective optimization of a multisegment multiaddition (MSMA) continuous plug-flow antisolvent crystallizer

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   09 Jun 2023 | Contributor(s):: Ridder, Bradley J., Majumder, Aniruddha, Nagy, Zoltan K.

   Crystallization is a major separation process in the pharmaceutical industry. Most crystallizations are performed batchwise, but there is great incentive for converting them to continuous operations. This paper investigates the modeling, simulation, and optimization of a special antisolvent...

2. Parametric, Optimization-Based Study on the Feasibility of a Multisegment Antisolvent Crystallizer for in Situ Fines Removal and Matching of Target Size Distribution

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   09 Jun 2023 | Contributor(s):: Ridder, Bradley J., Majumder, Aniruddha, Nagy, Zoltan K.

   We have computationally investigated the use of the multisegment, multiaddition, plug-flow crystallizer (MSMA-PFC) for use in producing pharmaceutical crystals. A population balance framework was used to model the crystallization process. The dissolution of crystals can be modeled when solubility...