Native starch as in situ binder for continuous twin screw wet granulation
Contributor(s):: Vandevivere, Lise, Portier, Christoph, Vanhoorne, Valerie, Hausler, Olaf, Simon, Denis, De Beer, Thomas, Vervaet, Chris
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied. Gelatinization of pea starch occurred in the barrel of the granulator using a poorly soluble excipient (anhydrous dicalcium phosphate), but the degree of gelatinization depended on the...