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1. Application of Continuous Flow for DIBAL-H Reduction and n-BuLi Mediated Coupling Reaction in the Synthesis of Eribulin Mesylate

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   Contributor(s):: Fukuyama, Takashi, Chiba, Hiroyuki, Kuroda, Hirofumi, Takigawa, Teiji, Kayano, Akio, Tagami, Katsuya

   Here we examined the use of continuous flow conditions for the final assembly of eribulin mesylate aimed to avoid cryogenic condition. The diisobutylaluminum hydride reduction of ester 2 to aldehyde 3 and n-butyllithium-mediated coupling of aldehyde 3 and sulfone fragment 4 to produce...