Skip to main content
Join CMKC members for a complimentary virtual event on December 10, 11am ET: CM MythBusters: https://bit.ly/3YXJynA. This is a fantastic opportunity to connect, collaborate, and debunk common myths about continuous manufacturing!
18.188.154.238

Tags: N-butyllithium-mediated coupling

More tags

All Categories (1-1 of 1)

  1. Application of Continuous Flow for DIBAL-H Reduction and n-BuLi Mediated Coupling Reaction in the Synthesis of Eribulin Mesylate

    0.0 out of 5 stars 

    24 Apr 2024 | Contributor(s):: Fukuyama, Takashi, Chiba, Hiroyuki, Kuroda, Hirofumi, Takigawa, Teiji, Kayano, Akio, Tagami, Katsuya

    Here we examined the use of continuous flow conditions for the final assembly of eribulin mesylate aimed to avoid cryogenic condition. The diisobutylaluminum hydride reduction of ester 2 to aldehyde 3 and n-butyllithium-mediated coupling of aldehyde 3 and sulfone fragment 4 to produce...