Continuous Manufacturing of High Quality Pharmaceutical Cocrystals Integrated with Process Analytical Tools for In-Line Process Control
Contributor(s):: Moradiya, Hiren G., Islam, Muhammad, Scoutaris, Nikolaos, Halsey, Sheelagh, Chowdhry, Babur Z., Douroumis, Dennis
A continuous manufacturing process for pharmaceutical indomethacin saccharine cocrystals was achieved by extrusion processing with high throughput. Down-stream milling and blending of the extrudates was followed by feeding the formulated cocrystals in a capsule-filling machine. By applying a...