Development of a Direct Photocatalytic C–H Fluorination for the Preparative Synthesis of Odanacatib
Contributor(s):: Halperin, Shira D., Kwon, Daniel, Holmes, Michael, Regalado, Erik L., Campeau, Louis-Charles, DiRocco, Daniel A., Britton, Robert
Late-stage C–H fluorination is an appealing reaction for medicinal chemistry. However, the application of this strategy to process research appears less attractive due to the formation and necessary purification of mixtures of organofluorines. Here we demonstrate that γ-fluoroleucine methyl...