Continuous flow synthesis of the URAT1 inhibitor lesinurad
Contributor(s):: Damião, Mariana C. F. C. B., Marçon, Henrique M., Pastre, Julio Cezar
Herein, the urate anion exchange transporter 1 (URAT1) inhibitor lesinurad is synthesized from commercially available building blocks by a five-step linear continuous flow sequence. Our previously developed continuous flow platform was successfully applied to generate the 3-thio-1,2,4-triazole...